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Lawrence R. Kleinberg, M.D. |
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Associate Professor of Radiation Oncology and Molecular Radiation Sciences |
Associate Professor of Oncology |
Associate Professor of Neurological Surgery |
Subspecialty
- Central Nervous System, Radiosurgery, Esophageal cancer |
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Dr. Kleinberg has an active program in the treatment of malignant and benign CNS diseases with external beam radiotherapy, brachtherapy, and radiosurgery (with Gamma Knife and with Brainlab system). |
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In addition, he treats esophageal cancer, primarily with combined modality protocols involving concurrent chemotherapy followed by surgical resection.
Dr. Kleinberg's research interests in the area of CNS tumors include (1) testing new agents in the therapy of Glioblastoma, (2)Improving fractionated stereotactic radiosurgery for acoustic neuroma, (3) Radiosurgery for multiple brain metastasis (4) Outcome with various techniques of radiosurgery (5) Quality of life issues.
In esophageal cancer, he participates in a research program with the goal of improving combined modality therapy. He is also the study chair for an Eastern Cooperative Oncology Group trial comparing Taxol/Cisplatin/RT vs. CPT11/Cisplatin/RT. Correlative laboratory studies are evaluating the prevalence and predictive importance of hypermethylation of a panel of genes. They are also testing TNFerade, an adenovirus vector containing the gene for Tumor Necrosis Factor. When the ECOG trial is complete, a trial testing Iressa/Taxol/Cisplatin/radiation will open. There will be correlative studies testing the impact of Iressa on elements of the downstream signaling pathways that may impact upon radiosensitivity and tumor growth. Dr. Kleinberg also leads the esophageal interest group of the GI committee of ECOG. |
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Education: |
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1981-85
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B.A. Biology with concentration in Genetics
University of Pennsylvania
Philadelphia, PA
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1985-89 |
M.D.
Yale University School of Medicine Medicine
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1989-90
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Intern in
Internal Medicine
Mount Sinai Medical Center
New York, New York
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1990-93
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Resident in
Radiation
Memorial Sloan-Kettering Cancer Center
New York, New York
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1994-95
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Business of Health Care, Certificate
Johns Hopkins University
Baltimore, Maryland
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Selected References |
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Publications |
1. Kleinberg L, Grossman SA, Carson K, Lesser G, O’Neill A, Pearlman J, Phillips P,
Herman T6, and Gerber M7 for the New Approaches to Brain Tumor Therapy (NABTT) CNS Consortium Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy: results of a phase II NABTT CNS consortium safety and efficacy study, Journal of Clinical Oncology, 20(14):3149-3155, 2002. |
2. Doty JR, Salazar JD, Forastiere AA, Heath EI, Kleinberg L, Heitmiller RF.
Postesophagectomy morbidity, mortality, and length of hospital stay after preoperative chemoradiation therapy. Ann Thorac Surg. 74(1):227-231, 2002. |
3. Kleinberg L, Knisely J, Heitmiller R, Zahurak M, Salem R, Burtness B, Heath EI, Forastiere AA. Mature survival results with preoperative cisplatin, protracted infusion
5-FU, and 44 Gy radiotherapy for esophageal cancer. International Journal of Radiation
Oncology, Biology and Physics. Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):328-34. |
4. Kleinberg L, Weingart J, Burger P, Carson K, Grossman SA, LI K, Allessandro O, Wharam, MD, Brem H. Clinical course and pathologic findings after gliadel ® and radiotherapy for newly diagnosed malignant glioma: implications for patient
management. Cancer Investigation. In Press. |
5. Tatter SB, Shaw EG, Rosenblum ML, Karvelis K, Kleinberg L, Weingart J, Olson JJ, Crocker IR, Brem S, Pearlman J, Fisher JD, Carson K, Grossman S. An inflatable balloon catheter (gliasite radiation therapy system) and liquid I-125 radiation source for treatment of recurrent malignant glioma: multi-center safety and feasibility trial. Clinical Oncology. J Neurosurg. 2003 Aug;99(2):297-303. |
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Abstracts: |
1. Health EI, Burtness BA, Kleinberg L, Salem R, Yang SC, Heitmiller RF, Phase II, parallel design study of preoperative combined modality therapy and the matrix metalloprotease (MMP) inhibitor prinomastat (P) in patients with esophageal adenocarcinoma (EA), Proceedings of ASCO 2002. |
2. Hughes M, Kleinberg L, Parisi M, Grossman SA Low CD4 counts and PCP prophylaxis in patients with primary brain tumors treated with steroids and radiation, Proceedings of ASCO 2003 |
3. Hughes M, Kleinberg L, Parisi M, Grossman SA., Low CD4 Counts and PCP Prophylaxis in Patients with
Primary Brain Tumors Treated with Steroids and Radiation, Proceedings of ASTRO, 2003 |
4. Kevin Khater, Lawrence Kleinberg, Alessandro Olivi, Lisa Jones, Stuart Grossman Incidence of Leptomeningeal Carcinomatosis for Cerebellar Metastases Managed Either with Surgery or Stereotactic Radiosurgery. Society for Neuro-Oncology |
5. Weiss, S., Kleinberg L, Wharam, M, Olivi, A Brem H, and Weingart, J Conservative Therapy with Delayed Radiotherapy for Low Grade Glioma Does Not Result in Increased Risk of Symptoms at Recurrence
Society for Neuro-Oncology |
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