Faculty Pages - Dr. Yonggong Zhang

Yonggong Zhang, M.D.

Research Associate

Dr. Yonggang Zhang is a Research Associate of Radiation Oncology and Molecular Radiation Sciences. His researches are focused on tumor radiation therapy, gene delivery radiation therapy in colon cancer and prostate cancer. Recently is in charged in Mass Spectrometry operation to detect DNA damage after radiation or exposed to other potential carcinogenic materials. He completed postdoctoral fellowship in Radiation Oncology at Johns Hopkins University.

Education:

1977-1982	MD - Shanghai Second Medical School
1982-1988	Medicine Residency - Department of Radiation Oncology Xinhua Hospital, Shanghai Second Medical School
1988-1992	Postdoctoral Fellowship Radiobiology Department of Oncology The Johns Hopkins School of Medicine

Selected References:

Publications

1. Zhang, Y. A study of changes in myocardium contraction following radiation treatment. J.Shanghai Tumor, 8:30-32,1988.

2. Williams, J.R., Zhang, Y., Dillehay, L.E. Sensitization processes in human tumor cells during protracted irradiation: Possible exploitation in the clinic. Int. J. Radiat. Biol. Phys. 24:699-704,1992.

3. Mayer, R., Dillehay, L.E., Shao, Y., Song, S., Zhang,Y.G., Bartholomew, R. M., Williams, J.R. A new Method for Determining Dose-Rate Distribution from Radioimmunotherapy Using Radiochromic Medium. Int. J. Radiation Onc. Biol.Phsi.,28:505-513, 1993.

4. Dillehay, L.E., Mayer,R., Zhang, Y.G., Song,S., Sho,Y., Mackensen, D.G., Williams, J.R. Use of Tremsstrahlung Radiation to Monitor Y-90 Tumor and Whole body activities during experimental radioimmunotherapy in mice. Cancer, Vol.73, No.3, 945-950,1994.

5. Dillehay, L.E., Mayer, R., Zhang, Y.G., Shao, Y., Song,S., Machensen, D.G., Williams, J.R. Prediction of tumor response to experimental radioimmunotherapy with Y-90 in nude mice. Int.J. radiation Onc,Biol. Phys., Vol 33,No.2, 417-427, 1995.

6. Waldman, T., Zhang, Y., Dillehay, L.E., Yu, J., Kinzler, K., Vogelstein, B., Williams, J. Cell-cycle arrest versus cell death in cancer therapy. Nature Medicine 3(9): 1034-1036, 1997.

7. Ravi, R.K., McMahon, M., Yonggang Z., Williams, J.R., Dillehay, L.E., Nelkin, B.D. and Mabry, M. Raf-1-induced cell cycle arrest in LNCap human prostate cancer cells. J. Cellular Biochemistry 72:458-469,1999.

8. Singh KK, Russel J, Sigala B, Zhang Y, Williams J, Kshav KF. Mitochondrial DNA determines the cellular response to cancer therapeutic agents. Oncogene Nov 19:18(48):6641-6646,1999.

9. Williams, J.R., Zhang, Y., Zhou, H., Osman , M., Kavet, R., Cuccinota, F., Docello, J.F., abd Dillehay, L.E., Predicting cancer rates in astronauts from animal carcinogenesis studies and cellular markers. Mutation Reserch, 430:255-269,1999.

10. Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, Williams J, Lengauer C, Kinzler KW, Vogelstein B. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin Invest 104(3):263-269, 1999.

11. Dicello JF, Christian A, Cucinotta FA, Gridley DS, Kathirithamby R, Mann J, Markhan AR, Moyers MF, Novak GR, Piantadosi S, Ricart-Arbona R, Simonson DM, Strandber JD, Vazquea M, Williams JR, Zhang Y, Zhou H, Huso D. In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates. Phys Med Biol. 2004 Aug 21:49(16): 3817-30.